किपा:Serpin mechanism.png
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Summary
| Description |
English: Serine proteases operate by a two-step catalytic mechanism. First, the substrate (blue) is attacked by the catalytic triad (red) to form an acyl-enzyme intermediate. The intermediate is typically resolved by hydrolysis by water. However, when the reactive centre loop (RCL) of a serpin is attacked, the conformational change (blue arrow) pulls the catalytic triad out of position, preventing it from completing catalysis. (Based on PDB: 1K9O, 1EZX) |
| Date | |
| Source | Own work |
| Author | Thomas Shafee |
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| Date/Time | Thumbnail | Dimensions | छ्य्लामि | Comment | |
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| current | ०९:५६, २२ डिसेम्बर २०१५ | | १,८०० × १,४८८ (५१३ KB) | Evolution and evolvability | Higher resolution |
| ०५:१९, १९ डिसेम्बर २०१५ |  | १,३६२ × १,१२६ (३०० KB) | Evolution and evolvability | Minor arrow correction | |
| ०५:०८, १९ डिसेम्बर २०१५ |  | १,३६२ × १,१२६ (३०० KB) | Evolution and evolvability | added arrow and removed transparency | |
| ०५:०४, १९ डिसेम्बर २०१५ |  | १,३६२ × १,११४ (३६० KB) | Evolution and evolvability | Cross-wiki upload from en.wikipedia.org |
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